Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232518 | 0.79 | ALDH1A1 (0.46) | ACHEALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL7232485 | 0.76 | MAOB (0.50) | ACHEALDH1A1KDM4EGAAALPL | |
| SCHEMBL7225961 | 0.74 | HSD17B14 (0.48) | ACHEALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL7226430 | 0.72 | HTT (0.49) | ALDH1A1KDM4EGAAKMT2AALPL | |
| SCHEMBL27544887 | 0.71 | ACHE (0.61) | ACHEALDH1A1KDM4ESLC6A4MAPT | |
| SCHEMBL1332779 | 0.71 | ALDH1A1 (0.68) | ALDH1A1KMT2AMAPTHPGDMAOB | |
| SCHEMBL7231004 | 0.70 | ALDH1A1 (0.44) | ACHEALDH1A1KDM4EGAAALPL | |
| SCHEMBL4866787 | 0.70 | ACHE (0.67) | ACHEALDH1A1KDM4ESLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL27470973 | 0.70 | ACHE (0.60) | ACHEALDH1A1KDM4EALPLALPG | |
| Hydrochloric Acid SCHEMBL3842041 | 0.69 | ACHE (0.66) | ACHEALDH1A1KDM4ESLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573267-B2 | Central nervous system disorders | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-06-03 | — | — | US | disclosed |
| US-20020019436-A1 | Useful aroyl aminoacyl pyrrole compounds | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-02-14 | — | — | US | disclosed |
| WO-2002002521-A2 | AROYL AMINOACYL PYRROLE COMPOUNDS AND THEIR PHARMACEUTICAL USE | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019436-A1 | Useful aroyl aminoacyl pyrrole compounds | ABAT, GAP43, AADAT | ACHE 37/4885ALDH1A1 1563/4885KDM4E 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.