Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225338 | 0.91 | SCN9A (0.33) | SLC6A3SMN1; SMN2SCN9A | |
| SCHEMBL7225932 | 0.90 | SCN9A (0.32) | SCN9A | |
| SCHEMBL7231932 | 0.90 | HTR4 (0.38) | SLC6A3 | |
| SCHEMBL7223469 | 0.90 | SLC6A2 (0.40) | SLC6A3SCN9A | |
| SCHEMBL7234386 | 0.90 | SLC6A4 (0.40) | SLC6A3 | |
| SCHEMBL7231524 | 0.90 | HTR3E (0.36) | — | |
| SCHEMBL7231491 | 0.88 | SLC6A2 (0.40) | SLC6A3KCNH2ABL1SCN9A | |
| SCHEMBL7231298 | 0.86 | KMT2A (0.38) | SMN1; SMN2 | |
| SCHEMBL7222888 | 0.86 | HPGD (0.35) | SLC6A3 | |
| SCHEMBL7116208 | 0.84 | POLB (0.36) | SMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |