Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | SLC8A1 | P32418 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231932 | 0.91 | HTR4 (0.38) | HTR4SLC6A3SLC6A2SLC6A4MAOB | |
| SCHEMBL7223246 | 0.91 | SLC6A3 (0.40) | SCN9ASLC6A3SMN1; SMN2 | |
| SCHEMBL7223469 | 0.91 | SLC6A2 (0.40) | SCN9AHTR4SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7225932 | 0.91 | SCN9A (0.32) | SCN9ASLC8A1 | |
| SCHEMBL7234386 | 0.91 | SLC6A4 (0.40) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7231524 | 0.91 | HTR3E (0.36) | SLC8A1 | |
| SCHEMBL7231298 | 0.87 | KMT2A (0.38) | POLBSMN1; SMN2 | |
| SCHEMBL7116208 | 0.85 | POLB (0.36) | SCN9APOLBSMN1; SMN2 | |
| SCHEMBL7230910 | 0.83 | SLC6A2 (0.40) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL7232332 | 0.83 | SLC6A2 (0.40) | HTR4SLC6A3SLC6A2SLC6A4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |