SCHEMBL722334

SCHEMBL722334

Clc1ccc(/C=C/c2ccccc2)c(Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
KDM4E B2RXH2 2/20 0.51
ALDH1A1 P00352 2/20 0.51
GAA P10253 2/20 0.51
MAPT P10636 2/20 0.51
MEN1 O00255 1/20 0.51
LMNA P02545 1/20 0.51
ALPL P05186 1/20 0.51
GLA P06280 1/20 0.51
ALPG P10696 1/20 0.51
PKM P14618 1/20 0.51
HPGD P15428 1/20 0.51
HTT P42858 1/20 0.51
KMT2A Q03164 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TDP1 Q9NUW8 1/20 0.50
TUBB4A P04350 2/20 0.49
TUBB P07437 2/20 0.49
TUBA3C P0DPH7 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL722335 1.00 NPC1 (0.51) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL17789112 0.89 MAOB (0.52) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL3295740 0.82 TDP1 (0.52) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL29074271 0.81 NFE2L2 (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL27473548 0.81 TRPA1 (0.60) KDM4ETUBB4ATUBBTUBA3CTUBA1B
SCHEMBL11018057 0.81 CYP19A1 (0.48) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL11021961 0.81 CYP19A1 (0.48) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL7118523 0.80 CYP19A1 (0.55) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL7118515 0.80 CYP19A1 (0.55) NPC1RAB9AKDM4EALDH1A1GAA
SCHEMBL5493438 0.79 CHAT (0.66) NPC1RAB9AKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9447022-B2 Triarylamine derivative and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-20 US disclosed
US-9447022-B2 Triarylamine derivative and electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-09-20 US disclosed
US-20160152552-A1 TRIARYLAMINE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-06-02 US disclosed
US-20160152552-A1 TRIARYLAMINE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2016-06-02 US disclosed
US-8445141-B2 Sulfonic acid group-containing polymer, method for producing the same, resin composition containing such sulfonic acid group-containing polymer, polymer electrolyte membrane, polymer electrolyte membrane/electrode assembly, and fuel cell TOYO BOSEKI KABUSHIKI KAISHA (JP) 2013-05-21 US disclosed
US-8216727-B2 Aromatic hydrocarbon based proton exchange membrane and direct methanol fuel cell using same TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-07-10 US disclosed
US-20120052411-A9 AROMATIC HYDROCARBON BASED PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME TOYO BOSEKI KABUSHIKI KAISHA (JP) 2012-03-01 US disclosed
US-20090075147-A1 Sulfonic acid group-containing polymer, method for producing the same, resin composition containing such sulfonic acid group-containing polymer, polymer electrolyte membrane, polymer electrolyte membrane/electrode assembly, and fuel cell TOYO BOSEKI KABUSHIKI KAISHA (JP) 2009-03-19 US disclosed
EP-1889863-A1 SULFONIC ACID GROUP-CONTAINING POLYMER, METHOD FOR PRODUCING SAME, RESIN COMPOSITION CONTAINING SUCH SULFONIC ACID GROUP-CONTAINING POLYMER, POLYMER ELECTROLYTE MEMBRANE, POLYMER ELECTROLYTE MEMBRANE/ELECTRODE ASSEMBLY, AND FUEL CELL Toyo Boseki Kabushiki Kasisha (JP) 2008-02-20 EP disclosed
US-20070207361-A1 AROMATIC HYDROCARBON BASED PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME TOYO BOSEKI KABUSHIKI KAISHA (JP) 2007-09-06 US disclosed
EP-1826846-A1 AROMATIC HYDROCARBON-BASE PROTON EXCHANGE MEMBRANE AND DIRECT METHANOL FUEL CELL USING SAME Toyo Boseki Kabushiki Kasisha (JP) 2007-08-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160152552-A1 TRIARYLAMINE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER TYR, NAT1, CRY1 NPC1 727/4885RAB9A 2407/4885KDM4E 2471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.