Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746814 | 0.65 | — | — | |
| Chloropromazine Sulfoxide SCHEMBL30463300 | 0.62 | CYP2D6 (0.62) | TP53CYP1A2CYP3A4HTR1ACYP2D6 | |
| Chloropromazine Sulfoxide SCHEMBL1155596 | 0.62 | CYP2D6 (0.62) | TP53CYP1A2CYP3A4HTR1ACYP2D6 | |
| Chloropromazine Sulfoxide SCHEMBL31540233 | 0.62 | CYP2D6 (0.62) | TP53CYP1A2CYP3A4HTR1ACYP2D6 | |
| Chloropromazine Sulfoxide SCHEMBL9724483 | 0.61 | LMNA (0.63) | TP53CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL6746847 | 0.61 | HTR2A (0.41) | HTR2ATDP1 | |
| SCHEMBL10925157 | 0.60 | CYP2D6 (0.62) | TP53CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL6748667 | 0.58 | HTR2A (0.31) | HTR2A | |
| SCHEMBL6746830 | 0.58 | ACHE (0.39) | MEN1KMT2ACHRM2SIGMAR1TDP1 | |
| SCHEMBL6746868 | 0.58 | DRD2 (0.39) | CYP1A2HTR1ADRD2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583138-B1 | Mediators or antagonists of the effects of histamine, leukotriene and the like; heterocyclic ring condensed benzothiazine compounds; inhibit the activation of the tyrosine kinase of 72 kDa | EISAI CO., LTD. (JP) | 2003-06-24 | — | — | US | claimed |