Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986232 | 0.86 | CYP11B1 (0.32) | CYP11B1CYP11B2CHRNB4CHRNA3 | |
| SCHEMBL7230196 | 0.86 | OPRL1 (0.38) | OPRL1CYP11B1CYP11B2SLC6A4SLC6A3 | |
| SCHEMBL7972022 | 0.85 | RIPK2 (0.32) | OPRL1RIPK2 | |
| SCHEMBL6573291 | 0.83 | OPRL1 (0.38) | OPRL1CYP11B1CYP11B2SLC6A4SLC6A3 | |
| SCHEMBL6574374 | 0.83 | OPRL1 (0.38) | OPRL1CYP11B1CYP11B2SLC6A4SLC6A3 | |
| SCHEMBL6617335 | 0.83 | OPRL1 (0.41) | OPRL1CYP11B1CYP11B2SLC6A4SLC6A3 | |
| SCHEMBL8174171 | 0.82 | OPRL1 (0.36) | OPRL1CYP11B1CYP11B2RIPK2 | |
| SCHEMBL8184433 | 0.82 | OPRL1 (0.36) | OPRL1CYP11B1CYP11B2RIPK2 | |
| SCHEMBL7971885 | 0.82 | KMT2A (0.34) | OPRL1CYP11B1CYP11B2RIPK2CHRNB4 | |
| SCHEMBL6617782 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573275-B1 | Insecticidal compositions comprising and to methods of combatting and controlling insect pests therewith. | SYNGENTA LIMITED (GB) | 2003-06-03 | — | — | US | disclosed |
| EP-0828739-B1 | BICYCLIC AMINES AS INSECTICIDES | SYNGENTA LTD (GB) | 2002-09-11 | — | — | EP | disclosed |
| US-6391883-B1 | INSECTICIDES | SYNGENTA LIMITED (GB) | 2002-05-21 | — | — | US | disclosed |
| US-6207676-B1 | Bicyclic amines | ZENECA LIMITED (GB) | 2001-03-27 | — | — | US | disclosed |
| EP-0828739-A1 | BICYCLIC AMINES AS INSECTICIDES | ZENECA LIMITED (GB) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037494-A1 | BICYCLIC AMINES AS INSECTICIDES | ZENECA LIMITED (GB) | 1996-11-28 | — | — | WO | disclosed |