Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225273 | 0.86 | GRM5 (0.32) | CHRNA7GRM5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7230402 | 0.84 | SLC6A2 (0.34) | ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL7233041 | 0.84 | SLC6A4 (0.34) | CHRNA7KMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL7234073 | 0.84 | CHRNB2 (0.34) | CHRNA7KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7231965 | 0.84 | CHRNA7 (0.36) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231859 | 0.82 | HDAC3 (0.34) | CHRNA7BCAT2ALDH1A1L3MBTL1HDAC3 | |
| SCHEMBL7225636 | 0.82 | CHRNA7 (0.34) | CHRNA7BCAT2KMT2AALDH1A1NPC1 | |
| SCHEMBL7232569 | 0.82 | NPC1 (0.34) | NPC1RAB9A | |
| SCHEMBL7223174 | 0.82 | CHRNA7 (0.33) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL374986 | 0.81 | CHRNA7 (0.60) | CHRNA7BCAT2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |