Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.33 |
| ▸ | HTR3B | O95264 | 4/20 | 0.33 |
| ▸ | HTR3A | P46098 | 4/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233218 | 0.84 | HPGD (0.34) | HPGD | |
| SCHEMBL7229680 | 0.83 | HPGD (0.36) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7234464 | 0.83 | F10 (0.34) | CHRNA7RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7225000 | 0.83 | NPC1 (0.34) | CHRNA7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7231438 | 0.83 | CHRNB2 (0.31) | CHRNA7MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7224349 | 0.83 | ALDH1A1 (0.35) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7231859 | 0.82 | HDAC3 (0.34) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7225018 | 0.82 | SLC6A4 (0.33) | CHRNA7 | |
| SCHEMBL7224430 | 0.82 | CHRNA7 (0.40) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7115104 | 0.82 | CHRNA7 (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |