Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 5/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233041 | 0.86 | SLC6A4 (0.34) | SLC6A4SLC6A3AKT1CHRNA7 | |
| SCHEMBL7224430 | 0.86 | CHRNA7 (0.40) | GRM5CHRNA7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7224957 | 0.86 | TAS1R3 (0.36) | SLC6A4SLC6A3CHRNA7 | |
| SCHEMBL7226168 | 0.83 | HSD17B1 (0.37) | GRM5SLC6A4SLC6A3 | |
| SCHEMBL7232950 | 0.83 | CHRNA7 (0.42) | AKT1CHRNA7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7234021 | 0.83 | SLC6A3 (0.39) | SLC6A4SLC6A3AKT1CHRNA7RAB9A | |
| SCHEMBL7224100 | 0.83 | USP7 (0.33) | SLC6A4SLC6A3AKT1 | |
| SCHEMBL7234073 | 0.83 | CHRNB2 (0.34) | SLC6A4SLC6A3AKT1CHRNA7NPC1 | |
| SCHEMBL7224323 | 0.83 | MEN1 (0.38) | RAB9ASMN1; SMN2 | |
| SCHEMBL7225018 | 0.82 | SLC6A4 (0.33) | SLC6A4SLC6A3AKT1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |