Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229750 | 0.85 | PKM (0.62) | KMT2APKMPOLBALDH1A1TDP1 | |
| SCHEMBL7226067 | 0.83 | PKM (0.61) | KMT2APKMALDH1A1TDP1MAPT | |
| SCHEMBL27457403 | 0.81 | ALDH1A1 (0.58) | KMT2APKMPOLBALDH1A1TDP1 | |
| SCHEMBL7222407 | 0.80 | FFAR4 (0.49) | KMT2APKMPOLBALDH1A1TDP1 | |
| SCHEMBL7223946 | 0.79 | CYTH2 (0.46) | KMT2APKMALDH1A1MAPTMEN1 | |
| SCHEMBL7225299 | 0.78 | ALDH1A1 (0.43) | KMT2APKMPOLBALDH1A1TDP1 | |
| SCHEMBL7225029 | 0.78 | ALDH1A1 (0.50) | KMT2ACA1CA2CA9PKM | |
| SCHEMBL7221797 | 0.77 | CYTH2 (0.43) | KMT2ACA2CA9PKMALDH1A1 | |
| SCHEMBL7221678 | 0.77 | CYTH2 (0.56) | KMT2ACA1CA2CA9PKM | |
| SCHEMBL7224301 | 0.76 | KMT2A (0.50) | KMT2APKMALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030203966-A1 | Nitromethylthiobenzene derivatives as aldose reductase inhihibitors | COLLONGES FRANCOIS (FR) | 2003-10-30 | — | — | US | disclosed |
| CN-1112356-C | Nitromethylthiobenzene derivatives as inhibitors of aldose reductase | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | CN | disclosed |
| US-6509499-B1 | Nervous system disorders, vision defects, diabetic retinopathy, neuropathic pain and kidney disorder treatment | MERCK PATENTGESELLSCHAFT MIT (DE) | 2003-01-21 | — | — | US | disclosed |
| EP-0946503-B1 | NITROMETHYLTHIOBENZENE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | MERCK PATENT GMBH (DE) | 2002-03-27 | — | — | EP | disclosed |
| CN-1241997-A | Nitromethylthiobenzene derivatives as inhibitors of aldose reductase | MERCK PATENT GMBH (DE) | 2000-01-19 | — | — | CN | disclosed |
| EP-0946503-A1 | NITROMETHYLTHIOBENZENE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | MERCK PATENT GmbH (DE) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028265-A1 | NITROMETHYLTHIOBENZENE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | MERCK PATENT GMBH (DE) | 1998-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203966-A1 | Nitromethylthiobenzene derivatives as aldose reductase inhihibitors | AKR1B1, ALDOA, AKR1C1 | KMT2A 4070/4885CA1 3129/4885CA2 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.