Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 11/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.40 |
| ▸ | HTR3B | O95264 | 5/20 | 0.40 |
| ▸ | HTR3A | P46098 | 5/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224982 | 0.84 | CHRNA7 (0.44) | CHRNA7MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7230230 | 0.83 | GAA (0.38) | CHRNA7MITFHSP90AA1MEN1KMT2A | |
| SCHEMBL7232904 | 0.83 | MITF (0.38) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223520 | 0.82 | CHRNA7 (0.45) | CHRNA7MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7225752 | 0.81 | CHRNA7 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7226017 | 0.80 | MAPT (0.46) | MITFHSP90AA1MEN1KMT2ANPSR1 | |
| SCHEMBL7223518 | 0.80 | CHRNA7 (0.60) | CHRNA7MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7225664 | 0.80 | HPGD (0.48) | CHRNA7MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7225837 | 0.80 | CHRNA7 (0.44) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7062848 | 0.80 | CHRNA7 (0.68) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |