Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.44 |
| ▸ | HTR3B | O95264 | 5/20 | 0.44 |
| ▸ | HTR3A | P46098 | 5/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223520 | 0.92 | CHRNA7 (0.45) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224685 | 0.84 | CHRNA7 (0.43) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7222867 | 0.84 | ICAM1 (0.38) | MEN1LMNAMAPTKMT2AF10 | |
| SCHEMBL7224240 | 0.84 | F10 (0.35) | MEN1LMNAMAPTKMT2AF10 | |
| SCHEMBL7224991 | 0.82 | ESRRG (0.46) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7231972 | 0.82 | ESRRG (0.46) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL375517 | 0.82 | CHRNA7 (0.57) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7223338 | 0.82 | CHRNA7 (0.57) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL7224704 | 0.81 | MAPKAPK2 (0.44) | MAPKAPK2MEN1LMNAMAPTKMT2A | |
| SCHEMBL7225375 | 0.81 | GUSB (0.40) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |