Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.42 |
| ▸ | RXRB | P28702 | 6/20 | 0.42 |
| ▸ | RXRG | P48443 | 6/20 | 0.42 |
| ▸ | RARA | P10276 | 4/20 | 0.42 |
| ▸ | RARB | P10826 | 4/20 | 0.42 |
| ▸ | RARG | P13631 | 4/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462110 | 0.89 | RXRA (0.41) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7225062 | 0.89 | AKR1B1 (0.38) | RXRARXRBRXRGRARARARB | |
| SCHEMBL15867091 | 0.81 | FTO (0.38) | AKR1B1FTOCYP26A1CYP26B1 | |
| SCHEMBL9850181 | 0.77 | RXRA (0.46) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7217796 | 0.76 | RARB (0.66) | RXRARXRBRXRGRARARARB | |
| SCHEMBL9850236 | 0.76 | RARB (0.45) | RARARARBRARGCYP26A1MEN1 | |
| SCHEMBL7217799 | 0.76 | RARB (0.66) | RXRARXRBRXRGRARARARB | |
| SCHEMBL9078166 | 0.76 | RARB (0.66) | RXRARXRBRXRGRARARARB | |
| SCHEMBL9053830 | 0.76 | AKR1B1 (0.35) | AKR1B1FTOCYP26A1CYP26B1 | |
| SCHEMBL7224928 | 0.75 | CYP26A1 (0.35) | RARARARBRARGAKR1B1FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |