Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.30 |
| ▸ | RARB | P10826 | 1/20 | 0.30 |
| ▸ | RARG | P13631 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054609 | 0.94 | CYP26A1 (0.35) | CYP26A1CYP26B1ALDH1A1SMN1; SMN2AKR1B1 | |
| SCHEMBL15867091 | 0.81 | FTO (0.38) | CYP26A1CYP26B1AKR1B1FTO | |
| SCHEMBL12171006 | 0.80 | FTO (0.36) | ALDH1A1SMN1; SMN2FTO | |
| SCHEMBL9053830 | 0.76 | AKR1B1 (0.35) | CYP26A1CYP26B1ALDH1A1AKR1B1FTO | |
| SCHEMBL9055810 | 0.75 | RARA (0.40) | CYP26A1CYP26B1ALDH1A1SMN1; SMN2GRIA1 | |
| SCHEMBL7224925 | 0.75 | RXRA (0.42) | CYP26A1CYP26B1AKR1B1FTORARA | |
| SCHEMBL7225062 | 0.74 | AKR1B1 (0.38) | CYP26A1CYP26B1ALDH1A1AKR1B1FTO | |
| SCHEMBL8462110 | 0.74 | RXRA (0.41) | CYP26A1CYP26B1AKR1B1FTORARA | |
| SCHEMBL9054394 | 0.73 | ALDH1A1 (0.42) | CYP26A1CYP26B1ALDH1A1AKR1B1FTO | |
| SCHEMBL9053844 | 0.73 | ALDH1A1 (0.42) | CYP26A1CYP26B1ALDH1A1AKR1B1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6624188-B1 | Administered to treat or prevent one or more of the diseases and conditions selected from the group consisting of dermatoses, atherosclerosis and restenosis resulting from neointimal hyperproliferation, non-malignant and | ALLERGAN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |
| US-5324840-A | Skin disorders | ALLERGAN, INC. (US) | 1994-06-28 | — | — | US | disclosed |