Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 11/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222867 | 0.91 | ICAM1 (0.38) | NTRK1KMT2A | |
| SCHEMBL7231813 | 0.85 | CHRNA7 (0.34) | GUSB | |
| SCHEMBL7223520 | 0.84 | CHRNA7 (0.45) | CYP2C19KMO | |
| SCHEMBL7223531 | 0.84 | CHRNB4 (0.40) | NPC1 | |
| SCHEMBL7230230 | 0.83 | GAA (0.38) | KMT2A | |
| SCHEMBL7226014 | 0.83 | SLC6A2 (0.41) | NPC1 | |
| SCHEMBL7225045 | 0.83 | SLC6A3 (0.41) | — | |
| SCHEMBL7231868 | 0.83 | SLC6A2 (0.41) | KMT2A | |
| SCHEMBL7225381 | 0.82 | HTR3E (0.37) | NPC1 | |
| SCHEMBL7230686 | 0.82 | CYP2C19 (0.35) | CYP2C19KMONPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |