SCHEMBL7234497

SCHEMBL7234497

COC(=O)C(C)Oc1cccc(Oc2cc(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c(F)cc2Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 15/20 0.38
ALDH1A1 P00352 1/20 0.35
PPOX P50336 2/20 0.35
BCAT2 O15382 1/20 0.33
BCAT1 P54687 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7227149 0.93 MEN1 (0.39) DHODHALDH1A1PPOX
SCHEMBL7221822 0.90 DHODH (0.37) DHODHALDH1A1PPOX
SCHEMBL3140584 0.89 BCAT1 (0.38) DHODHPPOXBCAT2BCAT1
SCHEMBL12981626 0.89 PPOX (0.43) DHODHALDH1A1PPOX
SCHEMBL7178022 0.89 PPOX (0.43) DHODHALDH1A1PPOX
SCHEMBL7225614 0.88 MRGPRX4 (0.38) DHODHPPOX
SCHEMBL6637980 0.88 DHODH (0.39) DHODH
SCHEMBL7227999 0.88 BCAT1 (0.47) BCAT2BCAT1
SCHEMBL6639012 0.87 DHODH (0.34) DHODHALDH1A1PPOX
SCHEMBL6644418 0.86 ACACB (0.36) DHODHPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6667413-B2 Aniline derivatives; herbicides; nonphytotoxic SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-23 US disclosed
US-20030130124-A1 Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED 2003-07-10 US disclosed
US-6451740-B2 HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-09-17 US disclosed
US-20020013466-A1 Uracil compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-31 US disclosed
EP-1106607-A2 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-06-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030130124-A1 Herbicides CBR3, CBR1, MT-CO1 DHODH 785/4885ALDH1A1 99/4885PPOX 939/4885
US-20020013466-A1 Uracil compounds and use thereof UNG, MRM1, OGG1 DHODH 754/4885ALDH1A1 85/4885PPOX 2274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.