Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CHRND | Q07001 | 1/20 | 0.39 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231120 | 0.89 | P2RY14 (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL7225066 | 0.88 | SLC6A4 (0.41) | CHRNB2CHRNA4CHRNA7CHRNA3CHRNB4 | |
| SCHEMBL7231998 | 0.88 | CHRNB2 (0.35) | CHRNB2CHRNA4MEN1KMT2ANPC1 | |
| SCHEMBL7223948 | 0.87 | TAS1R3 (0.36) | CHRNB2CHRNA4CHRNA7CHRNA3CHRNB4 | |
| SCHEMBL7224471 | 0.85 | F10 (0.35) | CHRNB2CHRNA4CHRNA7CHRNA3CHRNB4 | |
| SCHEMBL7233323 | 0.85 | ESR1 (0.37) | ALDH1A1HPGD | |
| SCHEMBL7225301 | 0.85 | CCNC (0.37) | CHRNB2CHRNA4 | |
| SCHEMBL7231245 | 0.84 | F10 (0.34) | CHRNB2CHRNA4CHRNA7CHRNA3CHRNB4 | |
| SCHEMBL7225557 | 0.84 | SLC8A1 (0.37) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7223716 | 0.84 | SCN9A (0.35) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |