Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7223716 | 0.93 | SCN9A (0.35) | HTR4SCN9ANPC1POLBRAB9A | |
| SCHEMBL7231120 | 0.89 | P2RY14 (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL7225892 | 0.88 | CHRNB2 (0.39) | CHRNB2CHRNA4NPC1RAB9AMEN1 | |
| SCHEMBL7225149 | 0.87 | HTR4 (0.37) | HTR4LMNANPC1POLBRAB9A | |
| SCHEMBL7232573 | 0.86 | CTSC (0.34) | HTR4CTSCNPC1POLBRAB9A | |
| SCHEMBL7225984 | 0.85 | P2RY14 (0.37) | SCN9ANPC1POLBRAB9A | |
| SCHEMBL7224866 | 0.84 | CTSC (0.40) | CTSCLMNANPC1MAPT | |
| SCHEMBL7116059 | 0.84 | POLB (0.39) | CHRNB2CHRNA4SCN9AMMP3MMP10 | |
| SCHEMBL7229845 | 0.83 | SLC6A3 (0.42) | NPC1POLBRAB9A | |
| SCHEMBL7226161 | 0.83 | SLC6A3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |