Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10974871 | 0.87 | TSHR (0.42) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL18644563 | 0.86 | LTA4H (0.41) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL5028320 | 0.82 | ALDH1A1 (0.42) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL7225914 | 0.80 | TSHR (0.44) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL4570827 | 0.80 | NQO1 (0.50) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL6460166 | 0.79 | TSHR (0.51) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL19885259 | 0.78 | NQO1 (0.48) | TSHRTDP1TP53CYP3A4ALDH1A1 | |
| SCHEMBL7220329 | 0.77 | TSHR (0.54) | TSHRTP53NPC1RAB9AMAPT | |
| SCHEMBL19480454 | 0.77 | TSHR (0.54) | TSHRTP53NPC1RAB9AMAPT | |
| SCHEMBL25235299 | 0.77 | GAA (0.51) | TDP1ALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207983-B | Use of a lubricating composition | 国际壳牌研究有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-106928126-B | Amide derivative, preparation method and pharmaceutical application thereof | 四川海思科制药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-106928126-A | A kind of amide derivatives and preparation method thereof and application pharmaceutically | 四川海思科制药有限公司 | 2017-07-07 | — | — | CN | disclosed |
| US-8026245-B2 | HIV replication inhibiting purine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-09-27 | — | — | US | disclosed |
| EP-1668011-B1 | HIV REPLICATION INHIBITING PURINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-02 | — | — | EP | disclosed |
| EP-1668011-B1 | HIV REPLICATION INHIBITING PURINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-02 | — | — | EP | disclosed |
| US-7465730-B2 | Treatment of neuropathic pain with 6H-pyrrolo[3,4-d]pyridazine compounds | MERCK & CO. INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-20060293330-A1 | Hiv replication inhibiting purine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | US | disclosed |
| US-20060154929-A1 | Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds | MERCK SHARP & DOHME CORP. | 2006-07-13 | — | — | US | disclosed |
| EP-1668011-A2 | HIV REPLICATION INHIBITING PURINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-14 | — | — | EP | disclosed |
| EP-1539168-A2 | TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO(3,4-D)PYRIDAZINE COMPOUNDS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2005028479-A2 | HIV REPLICATION INHIBITING PURINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-31 | — | — | WO | disclosed |
| WO-2004006836-A2 | TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO[3,4-D]PYRIDAZINE COMPOUNDS | MERCK & CO., INC. (US) | 2004-01-22 | — | — | WO | disclosed |
| CN-1061962-A | INDENOINDOLE COMPOUNDS | UNIV BATH (GB) | 1992-06-17 | — | — | CN | disclosed |
| EP-0043716-B1 | PHOTOSENSITIVE COMPOSITION AND PATTERN FORMING PROCESS USING SAME | Hitachi, Ltd. (JP) | 1985-04-10 | — | — | EP | disclosed |
| US-4409313-A | Powder deposition to form pattern on light imaged photosensitive diazonium salt coating having salt of aromatic amine | HITACHI, LTD. (JP) | 1983-10-11 | — | — | US | disclosed |
| US-4377630-A | COMPRISING AN AROMATIC DIAZONIUM SALT AND N,N-DIALKYL ANILINE SALT | HITACHI, LTD. (JP) | 1983-03-22 | — | — | US | disclosed |
| EP-0043716-A2 | Photosensitive composition and pattern forming process using same | Hitachi, Ltd. (JP) | 1982-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154929-A1 | Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds | GRIN2C, CACNA1C, CACNG4 | TSHR 2114/4885TDP1 2908/4885TP53 3787/4885 |
| US-20060293330-A1 | Hiv replication inhibiting purine derivatives | NSUN2, PRMT7, NNMT | TSHR 4203/4885TDP1 1989/4885TP53 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.