Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226150 | 0.77 | KEAP1 (0.47) | KEAP1TTRALDH1A1KDM4ECA1 | |
| SCHEMBL7226887 | 0.74 | HKDC1 (0.37) | TTRLMNAHPGDHIF1ACYP3A4 | |
| SCHEMBL22190040 | 0.66 | KEAP1 (0.63) | KEAP1TTRALDH1A1KDM4ECA1 | |
| SCHEMBL9173657 | 0.65 | TTR (0.70) | TTRALDH1A1CA1CA2HPGD | |
| SCHEMBL9328908 | 0.64 | CA1 (0.52) | TTRALDH1A1CA1CA2MEN1 | |
| SCHEMBL7432075 | 0.64 | CA1 (0.52) | ALDH1A1CA1CA2CYP1A2CYP3A4 | |
| SCHEMBL30479662 | 0.64 | CA1 (0.52) | ALDH1A1CA1CA2CYP1A2CYP3A4 | |
| SCHEMBL11142031 | 0.61 | APAF1 (0.52) | TTRALDH1A1KDM4ECA1CA2 | |
| SCHEMBL7927327 | 0.61 | MEN1 (0.57) | TTRALDH1A1KDM4ECA1CA2 | |
| SCHEMBL6498591 | 0.61 | HSD17B10 (0.58) | KEAP1TTRALDH1A1KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545011-B2 | PARP (poly(adenosine 5'-diphospho-ribose) polymerase) inhibitors | GUILFORD PHARMACEUTICALS INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | EISAI INC. | 2002-03-28 | — | — | US | disclosed |
| WO-2002006240-A1 | SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[IMN] PHENANTHRIDINE-5-ONES, DERIVATIVES THEREOF AND THEIR USES | GUILFORD PHARMACEUTICALS INC. (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | PARP1, PARP2, PARP4 | KEAP1 718/4885TTR 4884/4885ALDH1A1 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.