Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 3/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013929 | 0.86 | TTR (0.45) | TTRDTYMKTSHRCYP3A4CASP6 | |
| SCHEMBL7226887 | 0.83 | HKDC1 (0.37) | HKDC1TTRDTYMKS100A4TSHR | |
| SCHEMBL10528832 | 0.81 | HKDC1 (0.71) | HKDC1TTRCYP3A4HIF1AHPGD | |
| SCHEMBL9672294 | 0.77 | HKDC1 (0.42) | HKDC1S100A4TSHRTRPV1TP53 | |
| SCHEMBL912596 | 0.76 | TTR (0.45) | TTRDTYMKTSHRCYP3A4CASP6 | |
| SCHEMBL204106 | 0.74 | TTR (0.55) | TTRDTYMKTSHRTP53CYP3A4 | |
| SCHEMBL10530960 | 0.74 | CASP6 (0.53) | HKDC1TTRTSHRCYP3A4HIF1A | |
| SCHEMBL21749958 | 0.74 | CA1 (0.49) | TTRDTYMKTSHRCASP6CYP1A2 | |
| SCHEMBL7234069 | 0.74 | S100A4 (0.40) | TTRS100A4TSHRTRPV1TP53 | |
| SCHEMBL4017658 | 0.73 | AKR1C2 (0.44) | TTRDTYMKTSHRHIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545011-B2 | PARP (poly(adenosine 5'-diphospho-ribose) polymerase) inhibitors | GUILFORD PHARMACEUTICALS INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | EISAI INC. | 2002-03-28 | — | — | US | disclosed |
| WO-2002006240-A1 | SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[IMN] PHENANTHRIDINE-5-ONES, DERIVATIVES THEREOF AND THEIR USES | GUILFORD PHARMACEUTICALS INC. (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | PARP1, PARP2, PARP4 | HKDC1 1599/4885TTR 4884/4885DTYMK 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.