Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 3/20 | 0.43 |
| ▸ | DTYMK | P23919 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18496986 | 0.85 | ATM (0.48) | TTRGPR35ATMTDP1MAPT | |
| SCHEMBL505189 | 0.83 | ALDH1A1 (0.50) | AKR1C2AKR1C1TTRDTYMKGPR35 | |
| SCHEMBL4013929 | 0.82 | TTR (0.45) | TTRDTYMKTSHRCASP6ATM | |
| SCHEMBL7055312 | 0.82 | GPR35 (0.54) | AKR1C2AKR1C1DTYMKGPR35TSHR | |
| SCHEMBL912596 | 0.82 | TTR (0.45) | TTRDTYMKTSHRCASP6ATM | |
| SCHEMBL4017244 | 0.81 | PDGFRB (0.44) | TTRTDP1MAPTMEN1KMT2A | |
| SCHEMBL21749958 | 0.81 | CA1 (0.49) | TTRDTYMKTSHRCASP6ATM | |
| SCHEMBL204106 | 0.81 | TTR (0.55) | TTRDTYMKGPR35TSHRTDP1 | |
| SCHEMBL13338213 | 0.81 | ALDH1A1 (0.56) | TTRDTYMKGPR35TDP1LMNA | |
| SCHEMBL9423000 | 0.81 | DTYMK (0.44) | AKR1C2AKR1C1TTRDTYMKGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731630-A1 | HOMOPHTHALAZINONE INDOLE PARP INHIBITORS AND METHODS OF USE | Valo Health, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| EP-4731631-A1 | BENZAMIDAZOLE DIAZAPINONE PARP INHIBITORS AND METHODS OF USE | Valo Health, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024261712-A1 | BENZAMIDAZOLE DIAZAPINONE PARP INHIBITORS AND METHODS OF USE | VALO HEALTH, INC. (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2024261711-A1 | HOMOPHTHALAZINONE INDOLE PARP INHIBITORS AND METHODS OF USE | VALO HEALTH, INC. (US) | 2024-12-26 | — | — | WO | disclosed |
| US-11866412-B1 | Acridin-9-one compounds as antibacterial agents | King Faisal University (SA) | 2024-01-09 | — | — | US | disclosed |
| CN-111868060-B | Dihydropyridino phthalazinone derivatives, preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-3341375-B1 | PROCESS FOR PREPARING PARP INHIBITOR, CRYSTALLINE FORMS, AND USES THEREOF | BEIGENE LTD (KY) | 2022-04-13 | — | — | EP | disclosed |
| CN-111868060-A | Dihydropyridophthalazinone derivative, preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2020-10-30 | — | — | CN | disclosed |
| US-10457680-B2 | Process for preparing a PARP inhibitor, crystalline forms, and uses thereof | BEIGENE, LTD. (KY) | 2019-10-29 | — | — | US | disclosed |
| WO-2019174607-A1 | DIHYDROPYRIDOPHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海艾力斯医药科技有限公司 | 2019-09-19 | — | — | WO | disclosed |
| WO-2016012956-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2016-01-28 | — | — | WO | disclosed |
| WO-2016012956-A1 | ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2016-01-28 | — | — | WO | disclosed |
| EP-2797919-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BeiGene, Ltd. (KY) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097226-A1 | FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS | BEIGENE, LTD. (KY) | 2013-07-04 | — | — | WO | disclosed |
| CN-101616892-A | The tricyclic compound that is used for the treatment of the iron imbalance | XENON PHARMACEUTICALS INC | 2009-12-30 | — | — | CN | disclosed |
| EP-2061755-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-05-27 | — | — | EP | disclosed |
| US-20090069408-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-12 | — | — | US | disclosed |
| US-20090069408-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-12 | — | — | US | disclosed |
| WO-2008109840-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008109840-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069408-A1 | TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS | TFRC, SLC40A1, FECH | AKR1C2 213/4885AKR1C1 140/4885TTR 175/4885 |
| US-10457680-B2 | Process for preparing a PARP inhibitor, crystalline forms, and uses thereof | PARP1, PARP2, PARP11 | AKR1C2 2012/4885AKR1C1 1852/4885TTR 4124/4885 |
| US-11866412-B1 | Acridin-9-one compounds as antibacterial agents | TOP1, TOP2A, TOP2B | AKR1C2 2578/4885AKR1C1 2786/4885TTR 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.