Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | HTR5A | P47898 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481529 | 0.88 | HDAC1 (0.48) | PKMKDM4EALDH1A1KMT2AHTR6 | |
| SCHEMBL6475174 | 0.83 | HTR5A (0.50) | KDM4EALDH1A1KMT2APTGDR2HTR5A | |
| Maleic Acid SCHEMBL6480578 | 0.81 | HTR6 (0.51) | PKMKDM4EALDH1A1KMT2AHTR6 | |
| Fumaric Acid SCHEMBL6480586 | 0.81 | HTR6 (0.51) | PKMKDM4EALDH1A1KMT2AHTR6 | |
| SCHEMBL6475974 | 0.79 | KCNA5 (0.43) | KDM4EALDH1A1KMT2APTGDR2HTR5A | |
| SCHEMBL6481873 | 0.79 | PTGDR2 (0.48) | KDM4EALDH1A1KMT2APTGDR2HSD17B10 | |
| SCHEMBL6476108 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1KMT2APTGDR2HDAC1 | |
| SCHEMBL6480591 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1KMT2APTGDR2HSD17B10 | |
| SCHEMBL7225632 | 0.77 | KMT2A (0.52) | KDM4EALDH1A1KMT2APTGDR2HDAC6 | |
| SCHEMBL5373029 | 0.77 | ENPP2 (0.53) | KDM4EALDH1A1PTGDR2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583135-B2 | Treating central nervous system disorders wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity). | PHARMACIA & UPJOHN COMPANY | 2003-06-24 | — | — | US | disclosed |