Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10702044 | 0.86 | HSP90AA1 (0.42) | CES1DNMT1HSP90AA1CYP3A4TSHR | |
| SCHEMBL5681748 | 0.86 | CES1 (0.52) | CES1DNMT1HSP90AA1CYP3A4TSHR | |
| SCHEMBL11601993 | 0.79 | CES1 (0.50) | CES1DNMT1HSP90AA1CYP3A4TSHR | |
| SCHEMBL8745733 | 0.78 | ADORA2A (0.60) | DNMT1CYP3A4TSHRTP53MEN1 | |
| SCHEMBL6905214 | 0.72 | TTR (0.64) | DNMT1MEN1KMT2ATDP1POLB | |
| SCHEMBL16870940 | 0.72 | TTR (0.54) | CES1DNMT1HSP90AA1MEN1KMT2A | |
| SCHEMBL31154504 | 0.72 | TTR (0.54) | CES1DNMT1HSP90AA1MEN1KMT2A | |
| SCHEMBL8987675 | 0.72 | HSP90AA1 (0.67) | CES1DNMT1HSP90AA1TP53TDP1 | |
| SCHEMBL8663125 | 0.72 | ALDH1A1 (0.43) | CYP3A4TSHRTP53MEN1KMT2A | |
| SCHEMBL9846520 | 0.71 | ELANE (0.53) | HSP90AA1CYP3A4TSHRTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545011-B2 | PARP (poly(adenosine 5'-diphospho-ribose) polymerase) inhibitors | GUILFORD PHARMACEUTICALS INC. | 2003-04-08 | — | — | US | disclosed |
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | EISAI INC. | 2002-03-28 | — | — | US | disclosed |
| WO-2002006240-A1 | SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[IMN] PHENANTHRIDINE-5-ONES, DERIVATIVES THEREOF AND THEIR USES | GUILFORD PHARMACEUTICALS INC. (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037904-A1 | Substituted 4,9-dihydrocyclopent a [imn] phenanthridine-5-ones, derivatives thereof and their uses | PARP1, PARP2, PARP4 | CES1 4159/4885DNMT1 239/4885HSP90AA1 2984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.