SCHEMBL7227481

SCHEMBL7227481

COc1cc(Cl)cc(C(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 4/20 0.44
PTGS2 P35354 4/20 0.44
CCR4 P51679 1/20 0.42
FLT1 P17948 5/20 0.41
FLT4 P35916 5/20 0.41
KDR P35968 5/20 0.41
ATM Q13315 1/20 0.38
STS P08842 1/20 0.38
P2RY1 P47900 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8069688 0.84 CCR4 (0.44) PTGS1PTGS2CCR4FLT1FLT4
SCHEMBL7235501 0.81 FLT1 (0.44) PTGS1PTGS2CCR4FLT1FLT4
SCHEMBL7235867 0.79 KMT2A (0.49) FLT1FLT4KDRSMN1; SMN2NPC1
SCHEMBL7233807 0.77 CTSA (0.51) PTGS1PTGS2CCR4FLT1FLT4
SCHEMBL7235513 0.76 PTGS2 (0.47) PTGS1PTGS2FLT1FLT4KDR
SCHEMBL9470041 0.76 PTGS2 (0.41) PTGS1PTGS2CCR4FLT1FLT4
SCHEMBL7226465 0.75 P4HTM (0.48) PTGS1PTGS2CCR4FLT1FLT4
SCHEMBL7232323 0.73 PTGS2 (0.56) PTGS1PTGS2ATM
SCHEMBL9461118 0.73 TUBB4A (0.39) FLT1FLT4KDRATMSMN1; SMN2
SCHEMBL11065364 0.73 SMN1; SMN2 (0.56) CCR4SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610853-B1 N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide KUREHA KAGAKU KOGYO K.K. (JP) 2003-08-26 US disclosed
EP-1069112-A1 N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-01-17 EP disclosed