SCHEMBL8069688

SCHEMBL8069688

COc1cc(OC)nc(C(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.42
FLT1 P17948 3/20 0.41
FLT4 P35916 3/20 0.41
KDR P35968 3/20 0.41
GAA P10253 1/20 0.40
ATM Q13315 1/20 0.40
CTSA P10619 1/20 0.40
STS P08842 1/20 0.40
NPSR1 Q6W5P4 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
MET P08581 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
CDK9 P50750 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39
TUBB2A Q13885 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8074044 0.86 FLT1 (0.52) CCR4SMN1; SMN2FLT1FLT4KDR
SCHEMBL7227481 0.84 PTGS1 (0.44) CCR4SMN1; SMN2FLT1FLT4KDR
SCHEMBL7012354 0.82 SMN1; SMN2 (0.40) SMN1; SMN2GAACTSANPSR1TUBB4A
SCHEMBL11065364 0.78 SMN1; SMN2 (0.56) CCR4SMN1; SMN2NPSR1MAPTTSHR
SCHEMBL7235501 0.76 FLT1 (0.44) CCR4FLT1FLT4KDRGAA
SCHEMBL7006978 0.74 KMT2A (0.54) SMN1; SMN2GAACTSAMAPT
SCHEMBL7233807 0.74 CTSA (0.51) CCR4SMN1; SMN2FLT1FLT4KDR
SCHEMBL9470041 0.73 PTGS2 (0.41) CCR4FLT1FLT4KDRATM
SCHEMBL7628463 0.73 SMN1; SMN2 (0.44) SMN1; SMN2FLT1FLT4KDRCTSA
SCHEMBL7226465 0.73 P4HTM (0.48) CCR4SMN1; SMN2FLT1FLT4KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0592680-B1 N-sulfonated carboxamide derivatives as fungicides for plants KUMIAI CHEMICAL INDUSTRY CO (JP) 2000-07-19 EP disclosed
US-5536837-A PLANT FUNGICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1996-07-16 US disclosed
US-5478799-A Herbicide for weeds and fungicide for crops KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-12-26 US disclosed
US-5444060-A Applying to control pathogenic fungi KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1995-08-22 US disclosed
EP-0592680-A1 N-SULFONYLATED, SIX-MEMBERED NITROGENOUS AROMATIC CARBOXAMIDE DERIVATIVE OR SALT THEREOF, PRODUCTION THEREOF, AND PEST CONTROL AGENT KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1994-04-20 EP disclosed