SCHEMBL7226465

SCHEMBL7226465

COc1ccc(C(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P4HTM Q9NXG6 2/20 0.48
CCR4 P51679 1/20 0.44
FLT1 P17948 3/20 0.43
FLT4 P35916 3/20 0.43
KDR P35968 3/20 0.43
NFE2L2 Q16236 2/20 0.42
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
GAA P10253 2/20 0.41
KDM4E B2RXH2 1/20 0.41
TUBB4A P04350 1/20 0.40
TUBB P07437 1/20 0.40
MET P08581 1/20 0.40
TUBA3C P0DPH7 1/20 0.40
CDK9 P50750 1/20 0.40
TUBA1B P68363 1/20 0.40
TUBA4A P68366 1/20 0.40
TUBB4B P68371 1/20 0.40
TUBB3 Q13509 1/20 0.40
TUBB2A Q13885 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7235501 0.80 FLT1 (0.44) CCR4FLT1FLT4KDRMEN1
SCHEMBL12936279 0.79 P4HTM (0.54) P4HTMMEN1KMT2AGAAKDM4E
SCHEMBL7233807 0.79 CTSA (0.51) CCR4FLT1FLT4KDRMEN1
SCHEMBL7235180 0.77 KMT2A (0.52) P4HTMMEN1KMT2AGAAMAPT
SCHEMBL7227481 0.75 PTGS1 (0.44) CCR4FLT1FLT4KDRPTGS1
SCHEMBL9470041 0.75 PTGS2 (0.41) CCR4FLT1FLT4KDRPTGS1
SCHEMBL7235857 0.75 ALKBH2 (0.55) P4HTMNFE2L2KMT2AGAA
SCHEMBL7227108 0.73 FBP1 (0.49) P4HTMMEN1KMT2A
SCHEMBL8069688 0.73 CCR4 (0.44) CCR4FLT1FLT4KDRGAA
SCHEMBL15922622 0.73 P4HTM (0.49) P4HTMMEN1KMT2AGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6610853-B1 N-(phenylsulfonyl)picolinamide derivatives, process for producing the same, and herbicide KUREHA KAGAKU KOGYO K.K. (JP) 2003-08-26 US disclosed
EP-1069112-A1 N-(PHENYLSULFONYL) PICOLINAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-01-17 EP disclosed