Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235144 | 0.80 | PARP14 (0.69) | PARP14P2RX7 | |
| SCHEMBL6631556 | 0.79 | P2RX7 (0.44) | P2RX7ADRA1BDRD2DRD3 | |
| SCHEMBL7234890 | 0.78 | PARP14 (0.68) | PARP14P2RX7DRD2DRD3TSHR | |
| Fumaric Acid SCHEMBL7231579 | 0.76 | PARP14 (0.62) | PARP14ADRA1BDRD2DRD3 | |
| Fumaric Acid SCHEMBL7231590 | 0.76 | PARP14 (0.62) | PARP14ADRA1BDRD2DRD3 | |
| Fumaric Acid SCHEMBL7226160 | 0.73 | PARP14 (0.56) | PARP14P2RX7DRD2DRD3 | |
| Fumaric Acid SCHEMBL7226163 | 0.73 | PARP14 (0.56) | PARP14P2RX7DRD2DRD3 | |
| SCHEMBL7234477 | 0.70 | KDM4E (0.47) | PARP14MEN1KMT2A | |
| SCHEMBL7226445 | 0.70 | KMT2A (0.58) | PARP14TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6619934 | 0.69 | ALDH1A1 (0.47) | DRD2DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610694-B1 | Suppressing histamine and/or eosinophil chemotaxis; treating allergic diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-08-26 | — | — | US | disclosed |
| EP-1120418-A1 | FUSED PYRIDAZINE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-08-01 | — | — | EP | disclosed |