SCHEMBL7228147

SCHEMBL7228147

O=c1c2ccccc2oc2c1oc1ccccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 10/20 0.67
KDM4E B2RXH2 4/20 0.67
ALDH1A1 P00352 3/20 0.67
CYP3A4 P08684 2/20 0.67
GLA P06280 1/20 0.67
MAPT P10636 1/20 0.67
HPGD P15428 1/20 0.67
PGAM1 P18669 1/20 0.67
CASP1 P29466 1/20 0.67
CASP7 P55210 1/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
HSD17B10 Q99714 1/20 0.67
ESR2 Q92731 3/20 0.57
KDM5A P29375 1/20 0.56
PTGS2 P35354 1/20 0.55
LMNA P02545 2/20 0.53
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
ESR1 P03372 1/20 0.50
DDR2 Q16832 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9065424 0.85 KDM4E (0.55) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL7234834 0.84 ESR2 (0.77) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL7237389 0.84 ESR2 (0.77) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL21666743 0.82 MAOA (0.67) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL7227675 0.80 MAOA (0.78) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL7236943 0.80 MAOA (0.78) MAOAKDM4EALDH1A1CYP3A4GLA
Xanthone SCHEMBL41161 0.80 MAOA (1.00) MAOAKDM4EALDH1A1CYP3A4GLA
Xanthone SCHEMBL29398266 0.80 MAOA (1.00) MAOAKDM4EALDH1A1CYP3A4GLA
SCHEMBL4696277 0.80 MAOA (0.90) MAOAKDM4EALDH1A1CYP3A4GLA
Xanthone SCHEMBL29358061 0.80 MAOA (1.00) MAOAKDM4EALDH1A1CYP3A4GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023280767-A1 SANGENNON FOR ANTIVIRAL TREATMENT Universität Wien (AT) 2023-01-12 WO disclosed
US-11332474-B2 Compound and organic light-emission device LG DISPLAY CO., LTD. (KR) 2022-05-17 US disclosed
US-20200048273-A1 COMPOUND AND ORGANIC LIGHT-EMISSION DEVICE LG DISPLAY CO., LTD. (KR) 2020-02-13 US disclosed
US-20160214982-A1 Radiosynthesis of Tau Radiopharmaceuticals THE GENERAL HOSPITAL CORPORATION 2016-07-28 US disclosed
US-6559177-B2 For therapy or inhibiting osteoporosis or inhibiting bone demineralization, inflammatory bowel disease, Crohn's disease, ulcerative proctitis, or colitis in mammal WYETH 2003-05-06 US disclosed
US-6559177-B2 For therapy or inhibiting osteoporosis or inhibiting bone demineralization, inflammatory bowel disease, Crohn's disease, ulcerative proctitis, or colitis in mammal WYETH 2003-05-06 US disclosed
US-20020183310-A1 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents WYETH 2002-12-05 US disclosed
US-20020183310-A1 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents WYETH 2002-12-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160214982-A1 Radiosynthesis of Tau Radiopharmaceuticals MAPT, HTR7, TTBK2 MAOA 227/4885KDM4E 3059/4885ALDH1A1 1907/4885
US-20200048273-A1 COMPOUND AND ORGANIC LIGHT-EMISSION DEVICE TRPC4, TRPA1, TRPC1 MAOA 1058/4885KDM4E 1601/4885ALDH1A1 721/4885
US-20020183310-A1 5,11-dioxa-benzo[b]fluoren-10-one and 5-oxa-11-thia-benzo[b]fluoren-10-ones as estrogenic agents ESR1, GPER1, ESR2 MAOA 716/4885KDM4E 806/4885ALDH1A1 758/4885
US-11332474-B2 Compound and organic light-emission device TRPC4, TRPA1, TRPC1 MAOA 1058/4885KDM4E 1601/4885ALDH1A1 721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.