Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 18/20 | 0.42 |
| ▸ | NOS1 | P29475 | 18/20 | 0.42 |
| ▸ | NOS2 | P35228 | 18/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7231887 | 0.99 | NOS3 (0.42) | NOS3NOS1NOS2CCR1CCR5 | |
| SCHEMBL7843813 | 0.87 | CCR1 (0.39) | NOS3NOS1NOS2CCR1CCR5 | |
| SCHEMBL7238645 | 0.81 | SMN1; SMN2 (0.37) | CCR1CCR5CCR8PLAU | |
| Hydrochloric Acid SCHEMBL7238267 | 0.79 | CCR1 (0.38) | NOS3NOS1NOS2CCR1CCR5 | |
| Hydrochloric Acid SCHEMBL7239723 | 0.73 | NOS1 (0.61) | NOS3NOS1NOS2 | |
| SCHEMBL7229274 | 0.73 | PIK3CA (0.39) | CCR1CCR5CCR8 | |
| Hydrochloric Acid SCHEMBL7231883 | 0.72 | PIK3CA (0.38) | CCR1CCR5CCR8 | |
| SCHEMBL7239613 | 0.72 | SMN1; SMN2 (0.46) | CCR1CCR5CCR8 | |
| Hydrochloric Acid SCHEMBL7229879 | 0.71 | NOS3 (0.59) | NOS3NOS1NOS2 | |
| SCHEMBL925682 | 0.70 | CCR1 (0.52) | NOS3NOS1NOS2CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |