Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.64 |
| ▸ | MMP9 | P14780 | 13/20 | 0.64 |
| ▸ | MMP3 | P08254 | 7/20 | 0.64 |
| ▸ | MMP13 | P45452 | 7/20 | 0.64 |
| ▸ | MMP1 | P03956 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233440 | 0.90 | MMP2 (0.81) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7229104 | 0.89 | MMP2 (0.79) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7225679 | 0.82 | MMP2 (0.80) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224271 | 0.81 | MMP2 (0.67) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230149 | 0.77 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL379517 | 0.74 | NPSR1 (0.48) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230599 | 0.72 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7234102 | 0.72 | MMP2 (0.54) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224250 | 0.72 | MMP2 (0.81) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7223222 | 0.71 | MMP2 (0.71) | MMP2MMP9MMP3MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |