Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.67 |
| ▸ | MMP9 | P14780 | 14/20 | 0.67 |
| ▸ | MMP3 | P08254 | 11/20 | 0.67 |
| ▸ | MMP13 | P45452 | 11/20 | 0.67 |
| ▸ | MMP1 | P03956 | 7/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233440 | 0.91 | MMP2 (0.81) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7229708 | 0.81 | MMP2 (0.64) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230599 | 0.75 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230149 | 0.71 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7222078 | 0.70 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7229104 | 0.69 | MMP2 (0.79) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224858 | 0.65 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7224224 | 0.65 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7230604 | 0.65 | MMP9 (0.49) | MMP2MMP9MMP3MMP13MMP1 | |
| SCHEMBL7231815 | 0.65 | MMP3 (1.00) | MMP2MMP9MMP3MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605604-B1 | Tumour necrosis factor alpha release inhibitors; efficiency treatment of cancers, rheumatic diseases, arthritis, ulcers, atherosclerosis, asthma | LES LABORATOIRES SERVIER (FR) | 2003-08-12 | — | — | US | disclosed |
| EP-1091937-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000473-A1 | CARBOXYLIC AND HYDROXAMIC ACID COMPOUNDS INHIBITING METALLOPROTEASES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 2000-01-06 | — | — | WO | disclosed |