Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 8/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226373 | 0.89 | P2RX7 (0.44) | P2RX7USP30AAK1 | |
| SCHEMBL7232527 | 0.89 | USP30 (0.42) | P2RX7USP30 | |
| SCHEMBL7225370 | 0.88 | USP30 (0.42) | P2RX7USP30FYNKDM1AAAK1 | |
| SCHEMBL7224277 | 0.85 | USP30 (0.43) | USP30AXLMERTKHSD17B1HSD17B2 | |
| SCHEMBL7223444 | 0.85 | HSD17B1 (0.49) | TYRO3HSD17B1HSD17B2 | |
| SCHEMBL7230934 | 0.84 | KDM1A (0.43) | USP30KDM1AHSD17B1HSD17B2 | |
| SCHEMBL7230386 | 0.84 | USP30 (0.38) | P2RX7USP30 | |
| SCHEMBL7231132 | 0.84 | MAPK11 (0.42) | USP30KDM1A | |
| SCHEMBL7224212 | 0.83 | USP30 (0.41) | P2RX7USP30 | |
| SCHEMBL7225292 | 0.83 | P2RX7 (0.43) | P2RX7USP30AXLMERTKKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |