Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228437 | 0.93 | YAP1 (0.42) | ITGB3ITGA2BPTPN1MAPK1YAP1 | |
| SCHEMBL7229341 | 0.88 | ITGB3 (0.45) | ITGB3ITGA2BPTPN1MAPK1YAP1 | |
| SCHEMBL7239121 | 0.83 | GRM2 (0.41) | ITGB3ITGA2BPTPN1MAPK1ADRB3 | |
| SCHEMBL7229825 | 0.82 | ADRB3 (0.39) | MAPK1ADRB3 | |
| SCHEMBL7236262 | 0.81 | ITGB3 (0.51) | ITGB3ITGA2BMAPK1ADRB3 | |
| SCHEMBL7237375 | 0.81 | YAP1 (0.44) | ITGB3ITGA2BPTPN1MAPK1YAP1 | |
| SCHEMBL7231433 | 0.80 | ITGB3 (0.47) | ITGB3ITGA2BPTPN1MAPK1YAP1 | |
| SCHEMBL7228439 | 0.80 | ADRB3 (0.37) | ADRB3 | |
| SCHEMBL7238639 | 0.80 | HRH3 (0.38) | ADRB3 | |
| SCHEMBL7229936 | 0.77 | YAP1 (0.48) | ITGB3ITGA2BPTPN1MAPK1YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |