Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237375 | 0.93 | YAP1 (0.44) | ITGB3ITGA2BYAP1PTPN1MAPK1 | |
| SCHEMBL8547886 | 0.88 | ITGB3 (0.46) | ITGB3ITGA2BYAP1ADRB3 | |
| SCHEMBL7229822 | 0.88 | ITGB3 (0.47) | ITGB3ITGA2BYAP1PTPN1MAPK1 | |
| SCHEMBL7232013 | 0.83 | ITGB3 (0.40) | ITGB3ITGA2BYAP1HRH2HRH1 | |
| SCHEMBL7228437 | 0.81 | YAP1 (0.42) | ITGB3ITGA2BYAP1PTPN1MAPK1 | |
| SCHEMBL7238373 | 0.78 | ITGB3 (0.43) | ITGB3ITGA2BYAP1PTPN1MAPK1 | |
| SCHEMBL7231433 | 0.77 | ITGB3 (0.47) | ITGB3ITGA2BYAP1PTPN1MAPK1 | |
| SCHEMBL7228282 | 0.77 | GRM2 (0.47) | ITGB3ITGA2BPTPN1 | |
| SCHEMBL7229611 | 0.77 | ITGB3 (0.46) | ITGB3ITGA2BYAP1PTPN1 | |
| SCHEMBL7230723 | 0.77 | ITGB3 (0.42) | ITGB3ITGA2BYAP1PTPN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602876-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2003-08-05 | — | — | US | disclosed |
| US-6204280-B1 | OXAZOLIDINONE DERIVATIVE, ANTICOAGULANT | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 2001-03-20 | — | — | US | disclosed |
| EP-0710657-B1 | Antagonists of adhesion receptors | MERCK PATENT GMBH (DE) | 1998-08-26 | — | — | EP | disclosed |
| EP-0710657-A1 | Antagonists of adhesion receptors | MERCK PATENT GmbH (DE) | 1996-05-08 | — | — | EP | disclosed |