Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230184 | 0.80 | MAOA (0.62) | MAOAMAOB | |
| SCHEMBL7228164 | 0.76 | MAOA (0.57) | MAOAMAOB | |
| SCHEMBL10734871 | 0.76 | POLB (0.60) | MAOAMAOBOPRK1SIGMAR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL11342344 | 0.75 | SMN1; SMN2 (0.58) | MAOAMAOBOPRK1SIGMAR1CYP1A2 | |
| SCHEMBL7228418 | 0.73 | KDM4E (0.62) | MAOAMAOBCYP2D6 | |
| SCHEMBL7235850 | 0.72 | MAOA (0.70) | MAOAMAOBCYP1A2CYP2D6 | |
| SCHEMBL7228236 | 0.71 | MAOA (1.00) | MAOAMAOBCYP1A2CYP2D6 | |
| SCHEMBL7228371 | 0.71 | IDO1 (0.53) | SIGMAR1CYP2D6 | |
| SCHEMBL27940425 | 0.70 | IDO1 (0.56) | SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL7235146 | 0.68 | MAOA (0.64) | MAOAMAOBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649623-B1 | Administering tetrahydropiperidine derivative; antidiabetic agents; hyperlipemia treatment; hypotensive agents | SHIONOGI & CO., LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1151993-A1 | CYCLIC AMINE DERIVATIVES AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |