Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235354 | 0.84 | HRH3 (0.60) | MAOAMAOBSMN1; SMN2HRH3KMT2A | |
| SCHEMBL7230184 | 0.82 | MAOA (0.62) | MAOAMAOBSMN1; SMN2HRH3KMT2A | |
| SCHEMBL7228164 | 0.78 | MAOA (0.57) | MAOAMAOBSMN1; SMN2HRH3KMT2A | |
| SCHEMBL7228236 | 0.78 | MAOA (1.00) | MAOAMAOBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL491864 | 0.77 | MAOA (0.59) | MAOAHRH3 | |
| SCHEMBL491593 | 0.76 | HRH3 (0.97) | LMNAMAPK1HTTSMN1; SMN2HRH3 | |
| SCHEMBL25364075 | 0.75 | MAOA (0.58) | MAOAMAOB | |
| SCHEMBL5856321 | 0.75 | HRH3 (0.94) | LMNAMAPK1HTTSMN1; SMN2HRH3 | |
| SCHEMBL7228418 | 0.75 | KDM4E (0.62) | MAOAMAOBLMNAMAPK1HTT | |
| SCHEMBL21004107 | 0.75 | HRH3 (0.80) | LMNAMAPK1HTTSMN1; SMN2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649623-B1 | Administering tetrahydropiperidine derivative; antidiabetic agents; hyperlipemia treatment; hypotensive agents | SHIONOGI & CO., LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1151993-A1 | CYCLIC AMINE DERIVATIVES AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |