Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.62 |
| ▸ | MAOB | P27338 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7228164 | 0.96 | MAOA (0.57) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7228418 | 0.93 | KDM4E (0.62) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7235146 | 0.82 | MAOA (0.64) | MAOAMAOBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7229891 | 0.80 | MAOA (0.55) | MAOAMAOB | |
| SCHEMBL7564110 | 0.80 | KDM4E (0.82) | KDM4EALDH1A1SMN1; SMN2POLBSLC6A4 | |
| SCHEMBL7235850 | 0.78 | MAOA (0.70) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7228236 | 0.77 | MAOA (1.00) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7235354 | 0.77 | HRH3 (0.60) | MAOAMAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7295502 | 0.76 | PPARG (0.63) | KDM4EALDH1A1SMN1; SMN2HTR5AHRH3 | |
| SCHEMBL14970474 | 0.75 | KDM4E (0.75) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649623-B1 | Administering tetrahydropiperidine derivative; antidiabetic agents; hyperlipemia treatment; hypotensive agents | SHIONOGI & CO., LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1151993-A1 | CYCLIC AMINE DERIVATIVES AND USES THEREOF | SHIONOGI & CO., LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |