Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237373 | 0.88 | POLB (0.34) | LMNASMN1; SMN2 | |
| SCHEMBL7499394 | 0.62 | PDE4B (0.50) | GAALMNASMN1; SMN2PDE5APDE4B | |
| SCHEMBL7502894 | 0.61 | PDE10A (0.48) | LMNASMN1; SMN2PDE4BPDE4D | |
| SCHEMBL720880 | 0.60 | GABRA1 (0.35) | LMNASMN1; SMN2 | |
| SCHEMBL5668412 | 0.60 | NPC1 (0.39) | SMN1; SMN2 | |
| SCHEMBL718683 | 0.59 | ALPL (0.34) | SMN1; SMN2 | |
| SCHEMBL31263081 | 0.59 | MAPT (0.44) | GAALMNA | |
| SCHEMBL7107025 | 0.59 | — | — | |
| SCHEMBL14331171 | 0.59 | GRIN2B (0.51) | SYKGRIN2BPDE5A | |
| SCHEMBL22312019 | 0.57 | POLQ (0.40) | GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620817-B1 | Antiinflammatory, antiarthritic agents; autoimmune and rheumatic diseases | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2003-09-16 | — | — | US | disclosed |