Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.30 |
| ▸ | HTR3B | O95264 | 3/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.30 |
| ▸ | HTR3A | P46098 | 3/20 | 0.30 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.30 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231792 | 0.89 | KMT2A (0.33) | KCNH2SLC6A3HTR3EHTR3BCHRNA7 | |
| SCHEMBL7231735 | 0.88 | MMP2 (0.36) | SMN1; SMN2CHRNA7 | |
| SCHEMBL7222908 | 0.87 | EPHX2 (0.34) | KDM4ESMN1; SMN2 | |
| SCHEMBL7226094 | 0.85 | CHRNA7 (0.42) | KCNH2KDM4ELMNASMN1; SMN2HTR3E | |
| SCHEMBL7233323 | 0.84 | ESR1 (0.37) | SLC6A3 | |
| SCHEMBL7232082 | 0.84 | CXCR2 (0.34) | KCNH2LMNASMN1; SMN2SLC6A3HTR3E | |
| SCHEMBL7225066 | 0.83 | SLC6A4 (0.41) | KDM4ESLC6A3CHRNA7 | |
| SCHEMBL7229845 | 0.83 | SLC6A3 (0.42) | SLC6A3 | |
| SCHEMBL7225149 | 0.83 | HTR4 (0.37) | KDM4ELMNASMN1; SMN2SLC6A3 | |
| SCHEMBL7232095 | 0.83 | CHRNA7 (0.34) | SLC6A3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |