Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 9/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232731 | 0.86 | ACKR3 (0.39) | FAAHACKR3CA12CA1CA2 | |
| SCHEMBL7233239 | 0.85 | CA12 (0.39) | ACKR3CA12CA1CA2CA4 | |
| SCHEMBL7224879 | 0.85 | AKT1 (0.39) | FAAHCES1SLC6A3 | |
| SCHEMBL7231889 | 0.85 | FAAH (0.49) | FAAH | |
| SCHEMBL7233040 | 0.84 | ACKR3 (0.53) | ACKR3 | |
| SCHEMBL7234886 | 0.84 | FAAH (0.46) | FAAHACKR3CA12CA1CA2 | |
| SCHEMBL7225896 | 0.84 | CA12 (0.39) | ACKR3CA12CA1CA2CA4 | |
| SCHEMBL7226619 | 0.84 | HDAC1 (0.46) | FAAHACKR3CA12CA1CA2 | |
| SCHEMBL7226238 | 0.83 | ACKR3 (0.35) | FAAHCES1ACKR3CA12CA1 | |
| SCHEMBL7231627 | 0.83 | CA12 (0.42) | ACKR3CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |