Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233445 | 0.90 | CA12 (0.41) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7234556 | 0.88 | CA12 (0.44) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7234886 | 0.87 | FAAH (0.46) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7226619 | 0.87 | HDAC1 (0.46) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7225896 | 0.87 | CA12 (0.39) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7231627 | 0.86 | CA12 (0.42) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7230583 | 0.85 | FAAH (0.44) | CA12CA1CA2CA4ACKR3 | |
| SCHEMBL7223707 | 0.85 | NPC1 (0.38) | TAS1R3TAS1R1TAS1R2KDM1A | |
| SCHEMBL7073214 | 0.84 | TUBB4A (0.47) | CA12CA1CA2CA4CHRNB2 | |
| SCHEMBL7231308 | 0.84 | FAAH (0.45) | CA12CA1CA2CA4CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |