Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.37 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 6/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844181 | 0.83 | KDR (0.40) | ALDH1A1MAPTLOXL2GPR119LOX | |
| SCHEMBL7229865 | 0.82 | CNR1 (0.43) | NPFFR1NPFFR2AAK1 | |
| SCHEMBL7842034 | 0.80 | PPARG (0.36) | PPARGALDH1A1MAPTDRD1LOXL2 | |
| SCHEMBL17560318 | 0.78 | HTR3E (0.50) | NPFFR1NPFFR2MAPTRAB9A | |
| SCHEMBL7842037 | 0.76 | F2 (0.37) | PPARGAAK1LOXL2LOXMAPK8 | |
| Hydrochloric Acid SCHEMBL7231281 | 0.75 | TAAR1 (0.55) | PPARGALDH1A1MAPTLOXL2LOX | |
| SCHEMBL7229573 | 0.74 | CCR1 (0.40) | NPFFR1NPFFR2AAK1ALDH1A1MAPT | |
| SCHEMBL7240889 | 0.73 | TRPV1 (0.39) | NPFFR1NPFFR2RAB9A | |
| SCHEMBL7230300 | 0.72 | ACACB (0.40) | NPFFR1NPFFR2AAK1MAPTMAPK8 | |
| SCHEMBL17560548 | 0.72 | NOS1 (0.47) | NPFFR1NPFFR2ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6521643-B1 | Prevention and/or treatment of nitric oxide synthasey medi-ated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, diabetes, ulcerative colitis, cerebral infarction, osteoarthritis | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-02-18 | — | — | US | disclosed |
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |