Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.32 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224240 | 0.90 | F10 (0.35) | MAPTMEN1KMT2ALMNAF10 | |
| SCHEMBL7231554 | 0.84 | HSD17B1 (0.37) | CHRNA7HSD17B1HSD17B2DYRK1ADYRK1B | |
| SCHEMBL7231860 | 0.84 | HSD17B1 (0.48) | CHRNA7HSD17B1HSD17B2DYRK1ADYRK1B | |
| SCHEMBL7223520 | 0.83 | CHRNA7 (0.45) | CYP2C19KMOCHRNA7DYRK1ADYRK1B | |
| SCHEMBL7232904 | 0.83 | MITF (0.38) | MAPTMEN1KMT2ACHRNA7F10 | |
| SCHEMBL7225375 | 0.82 | GUSB (0.40) | CYP2C19KMOKMT2ANPC1 | |
| SCHEMBL7231206 | 0.82 | HSD17B1 (0.37) | MAPTCHRNA7HSD17B1HSD17B2RAB9A | |
| SCHEMBL7226168 | 0.82 | HSD17B1 (0.37) | HSD17B1HSD17B2F10KDM4E | |
| SCHEMBL7194554 | 0.82 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL7231965 | 0.81 | CHRNA7 (0.36) | CHRNA7HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |