Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7232218 | 0.89 | HDAC6 (0.48) | HDAC1HDAC6FAAHNPC1RAB9A | |
| SCHEMBL7233865 | 0.88 | HDAC1 (0.49) | HDAC1HDAC6GRIN2B | |
| SCHEMBL7231308 | 0.87 | FAAH (0.45) | HDAC1HDAC6FAAH | |
| SCHEMBL7223806 | 0.86 | HDAC1 (0.38) | HDAC1HDAC6FAAH | |
| SCHEMBL7225821 | 0.86 | HDAC1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL7234886 | 0.86 | FAAH (0.46) | HDAC1HDAC6FAAHPAX8 | |
| SCHEMBL7232162 | 0.86 | HDAC1 (0.50) | HDAC1HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7232700 | 0.86 | FAAH (0.46) | HDAC1HDAC6FAAH | |
| SCHEMBL7226103 | 0.85 | SLC9A1 (0.47) | HDAC1HDAC6NPC1RAB9AKMT2A | |
| SCHEMBL7073214 | 0.85 | TUBB4A (0.47) | HDAC1HDAC6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |