Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264609 | 0.74 | RAB9A (0.46) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL5172016 | 0.71 | RAB9A (0.57) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL26260010 | 0.66 | ALDH1A1 (0.48) | KDRAURKAMEN1KMT2AKDM4E | |
| SCHEMBL935681 | 0.65 | KDR (0.65) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL5051826 | 0.64 | KDR (0.68) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL10176240 | 0.63 | KDR (0.61) | KDRAURKARAB9AMEN1KMT2A | |
| Methane SCHEMBL28704887 | 0.62 | KDR (0.66) | KDRAURKARAB9AMEN1KMT2A | |
| Benzene SCHEMBL27629233 | 0.62 | RAB9A (0.69) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL374022 | 0.62 | RAB9A (0.74) | KDRAURKARAB9AMEN1KMT2A | |
| SCHEMBL29631691 | 0.62 | RAB9A (0.74) | KDRAURKARAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6653321-B1 | Stimulating kinase activity of insulin receptor; type II diabetes; hyperglycemia | TELIK, INC. | 2003-11-25 | — | — | US | claimed |