Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRND | Q07001 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7233574 | 0.88 | DGAT1 (0.33) | USP30SMYD3CHRNB2CHRNA4 | |
| SCHEMBL7225735 | 0.88 | CHRNB2 (0.34) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL7231098 | 0.88 | HCRTR1 (0.37) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7223713 | 0.86 | CHRNA7 (0.34) | USP30CHRNB2CHRNA4HTR3EHTR3B | |
| SCHEMBL7231186 | 0.84 | CHRNA7 (0.33) | SLC6A2SLC6A4SLC6A3CHRNA1CHRNG | |
| SCHEMBL7224375 | 0.84 | SLC6A2 (0.38) | SMYD3SLC6A2SLC6A4SLC6A3ICAM1 | |
| SCHEMBL7225137 | 0.83 | GRM5 (0.35) | USP30SLC6A2SLC6A4SLC6A3ICAM1 | |
| SCHEMBL7225799 | 0.82 | SLC6A2 (0.36) | USP30SMYD3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7225406 | 0.81 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7230414 | 0.81 | USP30 (0.40) | USP30SMYD3CHRNB2CHRNA4HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-6562816-B2 | Alpha 7 nicotine acetylcholine receptor agonist anti-psychotic agent, with reduced side effects | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |