Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | AKT2 | P31751 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 7/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7224641 | 0.93 | KDM4E (0.33) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL31579337 | 0.91 | CNR2 (0.34) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL15767503 | 0.73 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL2398490 | 0.68 | NUDT1 (0.40) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL5808966 | 0.68 | RAB9A (0.39) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL6102107 | 0.68 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL15719337 | 0.67 | DYRK1A (0.34) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL30060259 | 0.67 | KDM4E (0.36) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL9560121 | 0.67 | DYRK1A (0.50) | ALDH1A1KDM4EHPGDGLAHSD17B10 | |
| SCHEMBL3671369 | 0.67 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558498-A1 | NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| CN-119546608-A | Novel imidazopyridine and pyrazolopyridine sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2024017857-A1 | NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| US-6642229-B2 | Treatment of adverse neurological conditions | MERCK SHARP & DOHME LTD. | 2003-11-04 | — | — | US | disclosed |