Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231891 | 0.87 | CYP19A1 (0.34) | CYP19A1 | |
| SCHEMBL7234235 | 0.86 | CYP3A4 (0.35) | CYP19A1ACHE | |
| SCHEMBL7231866 | 0.81 | CYP19A1 (0.35) | CYP19A1NR1D1 | |
| SCHEMBL8550129 | 0.81 | CYP19A1 (0.35) | CYP19A1NR1D1 | |
| SCHEMBL7234703 | 0.79 | MTNR1A (0.37) | CYP19A1ACHE | |
| SCHEMBL7235416 | 0.77 | CYP19A1 (0.38) | CYP19A1NR1D1ACHEKMT2A | |
| SCHEMBL7232863 | 0.76 | CTSS (0.34) | FNTAFNTBNR1D1METAP2METAP1 | |
| SCHEMBL7852448 | 0.74 | ECE1 (0.37) | CYP19A1FNTAFNTBKMT2A | |
| SCHEMBL8547281 | 0.74 | KEAP1 (0.32) | CYP19A1KMT2A | |
| SCHEMBL9132721 | 0.72 | CYP19A1 (0.31) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541491-B1 | Treating ras mediated diseases, especially cancer. | ZENECA LIMITED (GB) | 2003-04-01 | — | — | US | disclosed |
| US-6232338-B1 | 4-Mercaptopyrrolidine derivatives as farnesyl transferase inhibitors | ZENECA LIMITED (GB) | 2001-05-15 | — | — | US | disclosed |