Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7231784 | 0.86 | ALDH1A1 (0.56) | ALDH1A1LMNAGBA1GFERHRH3 | |
| Hydrochloric Acid SCHEMBL10728487 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAGBA1GFERHRH3 | |
| SCHEMBL6221690 | 0.83 | TAAR1 (0.50) | ALDH1A1TDP1HRH3LOXL2MAOB | |
| SCHEMBL10690328 | 0.81 | LMNA (0.80) | ALDH1A1LMNAHRH3SIGMAR1HRH4 | |
| SCHEMBL3153045 | 0.77 | ALDH1A1 (0.88) | ALDH1A1LMNATDP1HRH3HRH4 | |
| SCHEMBL54966 | 0.77 | ALDH1A1 (0.96) | ALDH1A1LMNAHRH3HRH4 | |
| SCHEMBL1241262 | 0.77 | ALDH1A1 (0.57) | ALDH1A1LMNAHRH3CYP11B1CYP11B2 | |
| SCHEMBL2791022 | 0.77 | MAOA (0.55) | ALDH1A1HRH3MAOA | |
| SCHEMBL12082407 | 0.77 | ALDH1A1 (0.59) | ALDH1A1LMNAGBA1HRH3 | |
| SCHEMBL1639608 | 0.76 | SIGMAR1 (0.65) | ALDH1A1LMNACYP3A4TDP1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6545035-B1 | Having effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells. | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-04-08 | — | — | US | disclosed |
| US-6319918-B1 | FOR LYMPHOMA OR SOLID TUMORS TREATMENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-20 | — | — | US | disclosed |
| WO-2000073297-A1 | SUBSTITUTED INDOLINONE AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-12-07 | — | — | WO | disclosed |
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |